Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive

@article{Kang1998HerpesVP,
  title={Herpes virus-mediated preproenkephalin gene transfer to the amygdala is antinociceptive},
  author={Wen Qian Kang and Marlene A. Wilson and Michael A. Bender and Joseph Charles Glorioso and Steven P Wilson},
  journal={Brain Research},
  year={1998},
  volume={792},
  pages={133-135}
}
To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. Rats infected with the virus expressing preproenkephalin showed a selective, naloxone-reversible abolition of phase 2 flinching behavior compared to rats infected with a control… CONTINUE READING
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