Herpes-virus Immunity and Acute Graft-versus-host Disease

  title={Herpes-virus Immunity and Acute Graft-versus-host Disease},
  author={J. W. Gratama and Th. Stijnen and Hans-Udo Weiland and A. C. Hekker and J. M. J. J. Vossen},
  journal={The Lancet},
The influence of pretransplant herpes-virus antibodies in 126 marrow-graft recipients and their HLA-identical (A, B, C, DR) sibling donors on the incidence of grades II-IV acute graft-versus-host disease (GVHD) was studied in relation to previously reported risk factors for GVHD. Logistic regression procedures were used to control for confounding factors. Increasing donor age (odds ratio 3.7 per decade; p = 0.02) and donor seronegativity for Epstein-Barr virus (EBV; odds ratio 10.1; p = 0.005… CONTINUE READING

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