Herpes vector-mediated expression of proenkephalin reduces bone cancer pain.

  title={Herpes vector-mediated expression of proenkephalin reduces bone cancer pain.},
  author={James R. Goss and Cara F Harley and Marina Mata and Mark E. O'Malley and William F Goins and Xiaoping Hu and Joseph Charles Glorioso and David J. Fink},
  journal={Annals of neurology},
  volume={52 5},
We examined whether a herpes simplex virus vector that expresses human proenkephalin could be used to attenuate nociception in a model of bone cancer pain in mice. Osteolytic sarcoma cells were implanted into the medullary space of the right femur, followed by a subcutaneous inoculation of a replication-defective herpes simplex virus vector expressing human proenkephalin (vector SHPE) or a lacZ-expressing control vector (vector SHZ). SHPE-inoculated mice demonstrated a significant, naltrexone… CONTINUE READING

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