Herpes simplex viruses in antiviral drug discovery.

  title={Herpes simplex viruses in antiviral drug discovery.},
  author={Luis M Schang},
  journal={Current pharmaceutical design},
  volume={12 11},
Since the 1950's, herpes simplex viruses (HSV) have played prominent roles in the development of antivirals. The first efficacious antivirals, as well as the first safe for systemic use, were developed against HSV. It was only in 1995 when the first antiviral against a target not validated first with HSV was approved for clinical use (sequinavir). The early successes of targeting HSV DNA replication were most influential in developing the concept that antiviral drugs must target viral proteins… CONTINUE READING

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