Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles.

@article{Koelle2002HerpesSV,
  title={Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles.},
  author={David M Koelle and Hongbo Chen and Christopher M McClurkan and Effie W. Petersdorf},
  journal={Blood},
  year={2002},
  volume={99 10},
  pages={3844-7}
}
Clonally expressed T-cell receptor alphabeta heterodimers are able to bind many different major histocompatibility complex/peptide combinations. This promiscuity is thought to be required for adequate surveillance against microbial and malignancy-associated antigens. After transplantation, T cells may react with nonself structures, contributing to graft-versus-host disease, in the case of hematopoietic stem cell transplantation, or graft failure, when the host immune system is preserved. We… CONTINUE READING