Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells.

@article{Kristen2015HerpesSV,
  title={Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells.},
  author={Henrike Kristen and Soraya Santana and Isabel Sastre and Mar{\'i}a Recuero and Mar{\'i}a J Bullido and Jes{\'u}s Aldudo},
  journal={Neurobiology of aging},
  year={2015},
  volume={36 10},
  pages={2737-47}
}
Herpes simplex virus (HSV) types 1 and 2 are neurotropic viruses that establish lifelong latent infections in neurons. Mounting evidence suggests that HSV-1 infection is involved in the pathogenesis of Alzheimer's disease (AD). The relationships between other herpesvirus infections and events associated with neurodegeneration have not, however, been extensively studied. The present work reports that HSV-2 infection leads to the strong accumulation of hyperphosphorylated tau and the amyloid… CONTINUE READING
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