Herpes simplex virus type 1 suppresses the interferon signaling pathway by inhibiting phosphorylation of STATs and janus kinases during an early infection stage.

@article{Yokota2001HerpesSV,
  title={Herpes simplex virus type 1 suppresses the interferon signaling pathway by inhibiting phosphorylation of STATs and janus kinases during an early infection stage.},
  author={Shin-Ichi Yokota and Noriko Yokosawa and Toru Kubota and Tatsuo Suzutani and Itsuro Yoshida and Shunsuke Miura and Kowichi Jimbow and Nobuhiro Fujii},
  journal={Virology},
  year={2001},
  volume={286 1},
  pages={119-24}
}
We examined the influence on the interferon (IFN) signaling pathway of infection with herpes simplex virus type 1 (HSV-1) strain VR3. Data from reporter gene assays showed that expression of both type I and type II IFN-inducible genes was dramatically suppressed during the early stage of HSV-1 infection (2 to 3 h postinfection). During these periods, phosphorylation levels of janus kinases (JAKs) and STATs did not increase after treatment of HSV-1-infected FL cells with IFN-alpha or IFN-gamma… CONTINUE READING

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