Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses.

@article{Perng1999HerpesSV,
  title={Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses.},
  author={Guey-chuen Perng and Susan M Slanina and Ada Yukht and Homayon Ghiasi and Anthony B. Nesburn and Steven L Wechsler},
  journal={Journal of virology},
  year={1999},
  volume={73 11},
  pages={9669-72}
}
The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for efficient spontaneous reactivation in the rabbit ocular model of HSV-1 latency and reactivation. LAT is also the only viral gene abundantly expressed during latency. Rabbits were ocularly infected with the wild-type HSV-1 strain McKrae or the McKrae-derived LAT null mutant dLAT2903. Serum neutralizing antibody titers were determined at various times during acute and latent infection. The… CONTINUE READING
2 Citations
18 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 18 references

Similar Papers

Loading similar papers…