Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line.

Abstract

During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 reactivation ability, takes place. To study the involvement of this transcription in HSV-1 replication in neuronal cells and consequently in viral latency, we constructed stably transfected neuronal cell lines… (More)

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@article{Mador1998HerpesSV, title={Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line.}, author={Nurith Mador and Dalia Goldenberg and Oren Cohen and Amos Panet and Israel Steiner}, journal={Journal of virology}, year={1998}, volume={72 6}, pages={5067-75} }