Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

  title={Herpes simplex virus type 1 in brain and risk of Alzheimer's disease},
  author={R. Itzhaki and W. Lin and Dazhuang Shang and G. Wilcock and G. A. Jamieson},
  journal={The Lancet},
  • R. Itzhaki, W. Lin, +2 authors G. A. Jamieson
  • Published 1997
  • Medicine
  • The Lancet
  • BACKGROUND The apolipoprotein E epsilon 4 (APOE-epsilon 4) allele is a risk factor for Alzheimer's disease (AD), but it is neither essential nor sufficient for development of the disease. Other factors-genetic or environmental-must therefore have a role. By means of a PCR we have detected herpes simplex virus type 1 (HSV1) in latent form in brains of elderly people with and without AD. We have postulated that limited reactivation of the virus causes more damage in AD patients than in elderly… CONTINUE READING
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