Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm.

@article{Phelan1997HerpesSV,
  title={Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm.},
  author={Anne Phelan and J. B. Clements},
  journal={The Journal of general virology},
  year={1997},
  volume={78 ( Pt 12)},
  pages={
          3327-31
        }
}
Herpes simplex virus type 1 (HSV-1) immediate early protein IE63, an essential nuclear protein, is pleiotropic in function and, at the post-transcriptional level, inhibits RNA splicing, interacts with cellular splicing small nuclear ribonucleoprotein particles (snRNPs), binds RNA and prevents the nucleocytoplasmic transport of intron-containing mRNAs. Here it is reported that IE63 is a nucleocytoplasmic shuttle protein able to travel from snRNP- and RNA-rich nuclear foci to the cytoplasm, where… CONTINUE READING
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Functional and genetic analysis of the role of Vmw 110 in herpes simplex virus replication

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The Control of Herpes Simplex Virus Gene Expression • 1991
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