Herpes simplex virus type 1 evades the effects of antibody and complement in vivo.

@article{Lubinski2002HerpesSV,
  title={Herpes simplex virus type 1 evades the effects of antibody and complement in vivo.},
  author={John M. Lubinski and Ming Jiang and Lauren M Hook and Yueh J. Chang and Chad Sarver and Dimitrios C. Mastellos and John D. Lambris and Gary H Cohen and Roselyn J Eisenberg and Harvey M. Friedman},
  journal={Journal of virology},
  year={2002},
  volume={76 18},
  pages={9232-41}
}
Herpes simplex virus type 1 (HSV-1) encodes a complement-interacting glycoprotein, gC, and an immunoglobulin G (IgG) Fc binding glycoprotein, gE, that mediate immune evasion by affecting multiple aspects of innate and acquired immunity, including interfering with complement components C1q, C3, C5, and properdin and blocking antibody-dependent cellular cytotoxicity. Previous studies evaluated the individual contributions of gC and gE to immune evasion. Experiments in a murine model that examines… CONTINUE READING
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Innate immunity, p. 35–91

  • C. A. Janeway, P. Travers, M. Walport, M. Shlomchik
  • 2001
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