Herpes simplex virus type 1 and Alzheimer’s disease

@article{Dobson1999HerpesSV,
  title={Herpes simplex virus type 1 and Alzheimer’s disease},
  author={Curtis B Dobson and Ruth F. Itzhaki},
  journal={Neurobiology of Aging},
  year={1999},
  volume={20},
  pages={457-465}
}
Until recently, the only risk factors implicated in noninherited cases of Alzheimer's disease were increasing age, Down's syndrome, and probably, head injury. Having found that herpes simplex type 1 virus (HSV1) is present in the brain of many elderly people, we discovered that it is a risk factor for Alzheimer's disease when in the central nervous system of APOE-epsilon4 allele carriers. On the basis of this result and our finding that apoE-epsilon4 is a risk factor for herpes labialis, we… Expand
[Herpes simplex virus type 1 as risk factor associated to Alzheimer disease].
TLDR
Studies regarding the routes of dissemination of HSV-1 from the peripheral ganglions to the CNS, as well as the possible cellular and molecular mechanisms implied in generating neuronal damage during latent and productive infection, are of much relevance. Expand
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TLDR
It seems that apoE epsilon2 is a risk factor for HSE, which is significantly higher than the value of 7% for the normal subjects. Expand
Evidence for the relation of herpes simplex virus type 1 to Down syndrome and Alzheimer's disease
TLDR
It is proposed that the detection of HSV‐1 genome and HSV •1 inducible protein IL‐6 not only shows the presence in human brain, but may indicate a role for HSV•1 in the process of neuroinflammation and apoptosis, known to occur in both neurodegenerative disorders, AD and DS. Expand
Effect of Apolipoprotein E on the Cerebral Load of Latent Herpes Simplex Virus Type 1 DNA
TLDR
It is shown that viral neuroinvasiveness depends directly on the overall ApoE dosage and especially on the presence of isoform apolipoprotein E4, which seems to facilitate HSV-1 latency in the brain much more so than apoE3. Expand
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TLDR
The up-to-date systematic review and meta-analysis suggest that HSV-1 infection is a risk factor of AD. Expand
Alzheimer ' s disease and the role of infectious Agents : A review
Alzheimer’s disease (AD) is considered as a neurodegenerative disease in elderly people. Several hypotheses have been proposed in the development of AD. Infection with pathogenic agents such asExpand
Association of HSV1 and apolipoprotein E-ε4 in Alzheimer’s disease
The results of Marques et al (2001) are very surprising in that only one brain specimen was found to be positive for herpes simplex virus type 1 (HSV1) in a group of 15 Alzheimer’s disease (AD)Expand
Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner
  • C. Carter
  • Biology, Medicine
  • International journal of Alzheimer's disease
  • 2010
TLDR
Alzheimer's disease is classified as an autoimmune disorder created by pathogen mimicry of key Alzheimer's disease-related proteins, which may well be prevented by vaccination and regular pathogen detection and elimination, and perhaps stemmed by immunosuppression or antibody adsorption-related therapies. Expand
Herpes Viruses Increase the Risk of Alzheimer's Disease: A Meta-Analysis.
TLDR
A meta-analysis of published data found an increased risk for AD when herpesviridae is present in the brain compared to controls and HSV1 together with the presence of the APOE ɛ4 allele increases the risk of developing AD. Expand
Vaccination prevents latent HSV1 infection of mouse brain
TLDR
Whether a vaccine of mixed HSV-1 glycoproteins (ISCOMs), which protects mice from latent HSv-1 infection of sensory ganglia, prevents HSV1 latency in the CNS, preventing their possible future usage in humans is found. Expand
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References

SHOWING 1-10 OF 76 REFERENCES
Herpes simplex virus type 1 in brain and risk of Alzheimer's disease
TLDR
The findings suggest that the combination of HSV1 in brain and carriage of an APOE-epsilon 4 allele is a strong risk factor for AD, whereas either of these features alone does not increase the risk of AD. Expand
Neurotropic viruses and Alzheimer's disease: a search for varicella zoster virus DNA by the polymerase chain reaction.
TLDR
The presence of one neurotropic virus--HSV1--and the absence of another--VZV--in aged human brains is consistent with a role for HSV1 in the aetiology of Alzheimer's disease. Expand
Herpes Simplex Virus Infections and Alzheimer’s Disease
TLDR
Although further studies are required to confirm a role for HSV1 in AD and to elucidate its underlying molecular basis, implicating a virus in the pathogenesis of this insidious disease clearly offers novel potential treatments. Expand
Latent herpes simplex virus type 1 in normal and Alzheimer's disease brains
TLDR
It is postulated that factors such as number or expression of viral genes and host susceptibility might be related to incidence of AD. Expand
Detection of herpes simplex virus (types 1 and 2) and human herpesvirus 6 DNA in human brain tissue by polymerase chain reaction.
TLDR
It is suggested that herpesvirus latency in the human CNS is a common occurrence but there is no obvious correlation with increased incidence in either demyelinating disease or schizophrenia. Expand
Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type
TLDR
The highly sensitive polymerase chain reaction has detected the viral thymidine kinase gene in post‐mortem brain from 14/21 cases of senile dementia of the Alzheimer type and 9/15 elderly normals, indicating the presence of Herpes simplex virus type 1 DNA is a region‐dependent feature of the aged brain. Expand
Prevalence of Alzheimer plaques in AIDS
TLDR
The findings support the view that a stimulus to an inflammatory response in the brain favours argyrophilic plaque formation in the brains of patients with AIDS. Expand
Herpes simplex virus genomes in human nervous system tissue analyzed by polymerase chain reaction
TLDR
The study has confirmed the previous demonstration of latent HSV in trigeminal ganglia in normal humans and assessed the frequency and distribution of HSV genomes in the nervous system tissues of patients dying of nonneurological causes. Expand
HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy
TLDR
Comparison of frequency of neurologic symptoms for subjects with and without the E4 isoform (E4(+)and E4(–), respectively) in an HIV cohort shows that long-term survivors of HIV infection with E4 may be at high risk for AD; conversely, gene–viral interactions may speed AD pathogenesis. Expand
Virus Infection of Peripheral Nerve
This chapter reviews the peripheral nerve diseases associated with herpes simplex virus (HSV), varicella-zoster virus (VZV), hepatitis B virus, human cytomegalovirus (HCMV), Epstein-Barr virus (EBV),Expand
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