Herpes simplex virus type 1 and Alzheimer’s disease

@article{Dobson1999HerpesSV,
  title={Herpes simplex virus type 1 and Alzheimer’s disease},
  author={C. Dobson and R. Itzhaki},
  journal={Neurobiology of Aging},
  year={1999},
  volume={20},
  pages={457-465}
}
  • C. Dobson, R. Itzhaki
  • Published 1999
  • Medicine
  • Neurobiology of Aging
  • Until recently, the only risk factors implicated in noninherited cases of Alzheimer's disease were increasing age, Down's syndrome, and probably, head injury. Having found that herpes simplex type 1 virus (HSV1) is present in the brain of many elderly people, we discovered that it is a risk factor for Alzheimer's disease when in the central nervous system of APOE-epsilon4 allele carriers. On the basis of this result and our finding that apoE-epsilon4 is a risk factor for herpes labialis, we… CONTINUE READING
    Infectious Agents and Neurodegeneration
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