Herpes simplex virus type-1 and -2 pathogenesis is restricted by the epidermal basement membrane

@article{Weeks2000HerpesSV,
  title={Herpes simplex virus type-1 and -2 pathogenesis is restricted by the epidermal basement membrane},
  author={Benjamin S. Weeks and Rajeev Ramchandran and Jason J. Hopkins and Harvey M. Friedman},
  journal={Archives of Virology},
  year={2000},
  volume={145},
  pages={385-396}
}
 Murine flank scarification with HSV-1 and -2 results in primary lesions at the site of inoculation within three days and lesions at secondary sites within four days. The severity of the infection can be given a numerical value or “score” which is derived from the number and size of these lesions. Using this model, we investigated the role of the epidermal… CONTINUE READING