Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.

@article{Martinez1996HerpesSV,
  title={Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.},
  author={Rik Martinez and Robert T. Sarisky and Peter C. Weber and Sandra K Weller},
  journal={Journal of virology},
  year={1996},
  volume={70 4},
  pages={2075-85}
}
Mutations in the alkaline nuclease gene of herpes simplex type 1 (HSV-1) (nuc mutations) induce almost wild-type levels of viral DNA; however, mutant viral yields are 0.1 to 1% of wild-type yields (L. Shao, L. Rapp, and S. Weller, Virology 195:146-162, 1993; R. Martinez, L. Shao, J.C. Bronstein, P.C. Weber, and S. Weller, Virology 215:152-164, 1996). nuc mutants are defective in one or more stages of genome maturation and appear to package DNA into aberrant or defective capsids which fail to… CONTINUE READING
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