Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.

  title={Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB.},
  author={Danna Hargett and Stephen L. Rice and Steven L. Bachenheimer},
  journal={Journal of virology},
  volume={80 21},
The ability of herpes simplex virus type 1 (HSV-1) to activate NF-kappaB has been well documented. Beginning at 3 to 5 h postinfection, HSV-1 induces a robust and persistent nuclear translocation of an NF-kappaB-dependent (p50/p65 heterodimer) DNA binding activity, as measured by electrophoretic mobility shift assay. Activation requires virus binding and entry, as well as de novo infected-cell protein synthesis, and is accompanied by loss of both IkappaBalpha and IkappaBbeta. In this study, we… CONTINUE READING


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