Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

@article{Woniak2009HerpesSV,
  title={Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques},
  author={M. Woźniak and AP Mee and R. Itzhaki},
  journal={The Journal of Pathology},
  year={2009},
  volume={217}
}
The brains of Alzheimer's disease sufferers are characterized by amyloid plaques and neurofibrillary tangles. [...] Key Method We used in situ polymerase chain reaction to detect herpes simplex virus type 1 DNA, and immunohistochemistry or thioflavin S staining to detect amyloid plaques. We discovered a striking localization of herpes simplex virus type 1 DNA within plaques: in Alzheimer's disease brains, 90% of the plaques contained the viral DNA and 72% of the DNA was associated with plaques; in aged normal…Expand
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