Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding.

@article{Martn2002HerpesSV,
  title={Herpes simplex virus tegument protein VP22 contains overlapping domains for cytoplasmic localization, microtubule interaction, and chromatin binding.},
  author={Ana Mart{\'i}n and Peter O'Hare and John McLauchlan and Gillian Elliott},
  journal={Journal of virology},
  year={2002},
  volume={76 10},
  pages={
          4961-70
        }
}
We have previously shown that the 301-amino-acid herpes simplex virus tegument protein VP22 exhibits a range of subcellular localization patterns when expressed in isolation from other virus proteins. By using live-cell analysis of cells expressing green fluorescent protein (GFP)-tagged VP22 we have shown that when VP22 is first expressed in the cell it localizes to the cytoplasm, where, when present at high enough concentrations, it can assemble onto microtubules, causing them to bundle and… CONTINUE READING

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