Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research.

@article{Carlezon2000HerpesSV,
  title={Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research.},
  author={William A Carlezon and Eric J Nestler and Rachael Lee Neve},
  journal={Critical reviews in neurobiology},
  year={2000},
  volume={14 1},
  pages={47-67}
}
There is an enormous initiative to establish causal relationships between brain biology (including patterns of gene expression) and behavior. Unfortunately, genetic intervention is not accomplished easily in the brain. One strategy is to engineer and deliver to the brain specialized viral vectors that carry a gene (or genes) of interest, thereby exploiting the natural ability of viruses to insert genetic information into cells. When delivered to the brain, these vectors cause infected cells to… CONTINUE READING