Herpes simplex virus hepatitis in macrophage-depleted mice: the role of massive, apoptotic cell death in pathogenesis.

@article{Irie1998HerpesSV,
  title={Herpes simplex virus hepatitis in macrophage-depleted mice: the role of massive, apoptotic cell death in pathogenesis.},
  author={Hiroshi Irie and Hiroyuki Koyama and Hajime Kubo and Akio Fukuda and Kiyoshi Aita and Tatsuro Koike and Atsuko Yoshimura and Tomoaki Yoshida and Junji Shiga and Tamara N Hill},
  journal={The Journal of general virology},
  year={1998},
  volume={79 ( Pt 5)},
  pages={1225-31}
}
Infection with herpes simplex virus or hepatitis viruses can lead to fulminant hepatitis, but there is controversy about the underlying conditions needed for such disease. To investigate how the impairment of host defences might be involved, macrophages were depleted by administration of silica to mice before intravenous injection with herpes simplex virus type 1 (HSV-1). Such mice died rapidly and their livers were yellowish and shrunken (acute yellow atrophy), and occasionally grossly… CONTINUE READING
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Herpes simplex virus type-1 infection of corneal epithelial cells induces apoptosis of the underlying keratocytes

  • S. E. Wilson, L. Pedrosa, R. Beuerman, J. M. Hill
  • Experimental Eye Research
  • 1997
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