Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.

@article{Farnsworth2007HerpesSV,
  title={Herpes simplex virus glycoproteins gB and gH function in fusion between the virion envelope and the outer nuclear membrane.},
  author={Aaron Farnsworth and Todd W. Wisner and Michael William Webb and Richard Roller and Gary H Cohen and Roselyn J Eisenberg and David C. Johnson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 24},
  pages={10187-92}
}
Herpesviruses must traverse the nuclear envelope to gain access to the cytoplasm and, ultimately, to exit cells. It is believed that herpesvirus nucleocapsids enter the perinuclear space by budding through the inner nuclear membrane (NM). To reach the cytoplasm these enveloped particles must fuse with the outer NM and the unenveloped capsids then acquire a second envelope in the trans-Golgi network. Little is known about the process by which herpesviruses virions fuse with the outer NM. Here we… CONTINUE READING
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