Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection.

@article{Johnson1989HerpesSV,
  title={Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection.},
  author={Robin M. Johnson and Patricia G. Spear},
  journal={Journal of virology},
  year={1989},
  volume={63 2},
  pages={819-27}
}
We showed that the expression of a single protein, glycoprotein D (gD-1), specified by herpes simplex virus type 1 (HSV-1) renders cells resistant to infection by HSV but not to infection by other viruses. Mouse (LMtk-) and human (HEp-2) cell lines containing the gene for gD-1 under control of the human metallothionein promoter II expressed various levels of gD-1 constitutively and could be induced to express higher levels with heavy metal ions. Radiolabeled viruses bound equally well to gD-1… CONTINUE READING