Herpes simplex virus brainstem encephalitis in an AIDS patient.

  title={Herpes simplex virus brainstem encephalitis in an AIDS patient.},
  author={Ronald L. Hamilton and Cristian L. Achim and Marjorie R. Grafe and J C Fremont and D K Miners and Clayton A Wiley},
  journal={Clinical neuropathology},
  volume={14 1},
We report a case of a virulent, atypical herpes simplex infection in the brainstem of a patient with Acquired Immune Deficiency Syndrome (AIDS) which was characterized by demyelination and oligodendroglial tropism. At autopsy the brainstem showed demyelination. Immunocytochemistry, in situ hybridization, and electron microscopy confirmed the presence of herpes simplex virus (HSV). Viral cultures demonstrated HSV type 1. Neuroinvasiveness and neurovirulence were studied by intraperitoneal… CONTINUE READING

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