Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities.

@article{Rice1989HerpesSV,
  title={Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities.},
  author={Stephen A. Rice and Li Sek Su and David Michael Knipe},
  journal={Journal of virology},
  year={1989},
  volume={63 8},
  pages={3399-407}
}
The HSV-1 alpha (immediate-early) protein ICP27 expressed in transfected cells can activate the expression of certain HSV-1 promoters as well as inhibit the transactivated expression of others. We constructed a set of plasmids encoding mutant ICP27 molecules truncated at their carboxyl termini and used transfection assays to determine the functional properties of the mutant proteins. A polypeptide containing the amino-terminal 263 amino acid residues of ICP27 retained partial ability to… CONTINUE READING

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