Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.

@article{Wang2014HerpesSV,
  title={Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.},
  author={Kezhen Wang and Liwen Ni and Shuai Wang and Chunfu Zheng},
  journal={Journal of virology},
  year={2014},
  volume={88 14},
  pages={7941-51}
}
Nuclear factor κB (NF-κB) plays important roles in innate immune responses by regulating the expression of a large number of target genes involved in the immune and inflammatory response, apoptosis, cell proliferation, differentiation, and survival. To survive in the host cells, viruses have evolved multiple strategies to evade and subvert the host immune response. Herpes simplex virus 1 (HSV-1) bears a large DNA genome, with the capacity to encode many different viral proteins to counteract… CONTINUE READING

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