Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection

@article{Burnett2012HerpesSV,
  title={Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infection},
  author={Heather F. Burnett and Timothy E. Audas and Genqing Liang and Rui Ray Lu},
  journal={Cell Stress and Chaperones},
  year={2012},
  volume={17},
  pages={473-483}
}
Accumulation of mis- and unfolded proteins during viral replication can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR). If unchecked, this process may induce cellular changes detrimental to viral replication. In the report, we investigated the impact of HSV-1 on the UPR during lytic replication. We found that HSV-1 effectively disarms the UPR in early stages of viral infection. Only ATF6 activation was detected during early infection, but with no… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS

8 Figures & Tables

Topics

Statistics

051015201620172018
Citations per Year

Citation Velocity: 7

Averaging 7 citations per year over the last 3 years.

Learn more about how we calculate this metric in our FAQ.