Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.

@article{Bailey2002HerpesSV,
  title={Herpes simplex virus 1 ICP0 co-localizes with a SUMO-specific protease.},
  author={Daniel Bailey and Peter G O'Hare},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 12},
  pages={2951-64}
}
Early during infection, the herpes simplex regulatory protein ICP0 promotes the proteasome-dependent degradation of a number of cellular proteins and the loss of a number of SUMO-1-modified protein isoforms, including PML. Recently, ICP0 has been shown to induce the accumulation of conjugated ubiquitin and function as a ubiquitin E3 ligase. However, certain aspects of the biochemistry, cell biology and the links between SUMO-1 conjugation/deconjugation and protein degradation remain unclear… CONTINUE READING