Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?

@article{Conrady2010HerpesST,
  title={Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?},
  author={Christopher D. Conrady and Douglas A. Drevets and Daniel J J Carr},
  journal={Journal of neuroimmunology},
  year={2010},
  volume={220 1-2},
  pages={1-9}
}
Herpes simplex virus type 1 (HSV-1) can induce a robust immune response initially thru the activation of pattern recognition receptors and subsequent type I interferon production that then shapes, along with other innate immune components, the adaptive immune response to the insult. While this response is necessary to quell virus replication, drive the pathogen into a "latent" state, and likely hinder viral reactivation, collateral damage can ensue with demonstrable cell death and foci of… CONTINUE READING
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