Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

@inproceedings{Petro2015HerpesST,
  title={Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease},
  author={Christopher D Petro and Pablo Almorox Gonz{\'a}lez and Natalia Cheshenko and Thomas Jandl and Nazanin Khajoueinejad and Ang{\`e}le B{\'e}nard and Mayami Sengupta and Betsy C. Herold and William R Jacobs},
  booktitle={eLife},
  year={2015}
}
Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safety of an HSV-2 virus deleted in gD-2 and complemented allowing a single round of replication on cells expressing HSV-1 gD (ΔgD(-/+gD-1)). Subcutaneous immunization of C57BL/6 or BALB/c mice with ΔgD(-/+gD1) provided 100% protection against lethal intravaginal or skin… CONTINUE READING

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