Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells.

@article{Barcy2001HerpesSI,
  title={Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells.},
  author={Serge Barcy and Lawrence Corey},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={6242-9}
}
HSV establish a lifelong persistent infection in their host even among immunocompetent persons. The viruses use a variety of immune evasion strategies, presumably to assist persistent replication in the human host. We have observed that infection of human B lymphoblastoid cells (B-LCL) by HSV resulted in a strong inhibition of their ability to induce CD4… CONTINUE READING