Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells.

@article{Barcy2001HerpesSI,
  title={Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells.},
  author={Serge Barcy and Lawrence Corey},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={
          6242-9
        }
}
HSV establish a lifelong persistent infection in their host even among immunocompetent persons. The viruses use a variety of immune evasion strategies, presumably to assist persistent replication in the human host. We have observed that infection of human B lymphoblastoid cells (B-LCL) by HSV resulted in a strong inhibition of their ability to induce CD4(+) T cell clone proliferation and cytokine secretion. This inhibitory effect occurs in a variety of both HSV- and HIV-specific clones from… CONTINUE READING
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