Herpes simplex genes: the blueprint of a successful human pathogen.

  title={Herpes simplex genes: the blueprint of a successful human pathogen.},
  author={Patricia Layzell Ward and Bernard Roizman},
  journal={Trends in genetics : TIG},
  volume={10 8},
The Herpes simplex virus genome encodes 75 proteins. Of these, only 37 are required for growth of the virus in culture. These essential genes encode functions related to entry of virus into cells, regulation of gene expression and replication and packaging of viral DNA into virions. The genes that are not essential for replication in culture play a key role in multiplication of the virus and its transfer from cell to cell, in complementing cellular functions lost as a consequence of viral… CONTINUE READING

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