Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain
@article{Esiri1982HerpesSE, title={Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain}, author={Margaret M. Esiri}, journal={Journal of the Neurological Sciences}, year={1982}, volume={54}, pages={209-226} }
236 Citations
Distribution of herpes simplex virus DNA in the brains of human long-term survivors of encephalitis
- Medicine, BiologyNeuroscience Letters
- 1993
Neurological disease and herpes simplex virus
- Medicine, BiologyActa Neuropathologica
- 2004
Only two patients with Alzheimer's disease showed areas of brain positive for HSV antigen (VA), which suggests “coincidental disease” processes within these two patients and means that any hypothesis implicating HSV as an aetiological agent in degenerative disease must still remain extremely speculative.
Herpes simplex virus antigen detection in human acute encephalitis:
- Biology, MedicineActa Neuropathologica
- 2004
Results suggests that, because of its high sensitivity, ABC method permits viral antigen detection not feasible with other methods, however, this method lacks of accuracy for HSV typing mainly because of probable antigens changes resulting from tissue processing.
Concurrent herpes simplex type 1 necrotizing encephalitis, cytomegalovirus ventriculoencephalitis and cerebral lymphoma in an AIDS patient
- Medicine, BiologyActa Neuropathologica
- 2004
Herpes simplex virus type 1 was shown in the nuclei and cytoplasm of certain neurons and astrocytes in the borders of the necrotized temporal lobe areas by immunohistochemistry, in situ hybridization and electron microscopy, whereas in situ Hybridization and immunohistsochemistry for CMV were negative in such areas.
Herpes simplex virus encephalitis in a mouse model: PCR evidence for CNS latency following acute infection
- BiologyJournal of the Neurological Sciences
- 1994
Immunohistological studies of immunoglobulin-containing cells and viral antigens in some inflammatory diseases of the nervous system.
- Medicine, Biology
- 1983
Herpes simplex encephalitis Immunohistological demonstration of spread of virus via olfactory pathways in mice
- BiologyJournal of the Neurological Sciences
- 1983
Immunocytochemical localization of herpes simplex virus antigen in the trigeminal ganglia of experimentally infected mice
- BiologyJournal of the Neurological Sciences
- 1984
Comparison of in situ DNA hybridization (ISH) and immunocytochemistry for diagnosis of herpes simplex virus (HSV) encephalitis in tissue
- Medicine, BiologyVirchows Archiv A
- 2004
Results demonstrate that immunocytochemistry and ISH are techniques of comparable sensitivity for detection of HSV in paraffin sections of acute necrotizing encephalitis brains; their combined use enhanced sensitivity, in the authors' hands, to 84%.
Resistance of rat CNS to brain stem infection with herpes simplex virus type 1
- BiologyActa Neuropathologica
- 2004
The observed relative resistance of brain stem-derived astrocytes to replicate HSV-1 might contribute to the ability of the brain stem to withstand infection during reactivation of this virus in the trigeminal neurons.
References
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Herpes simplex encephalitis Immunohistological demonstration of spread of virus via olfactory pathways in mice
- BiologyJournal of the Neurological Sciences
- 1983
Herpes simplex encephalitis: a clinical and pathological analysis of twenty-two cases
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- 1973
The present problem is that the firmest diagnosis is made in those patients who are most seriously ill, so that what have come to be accepted as the 'typical' clinical picture and the characteristic histopathology may in fact represent only one part of a wide clinical spectrum.
THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS : I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING
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The pathogenesis of herpes simplex virus encephalitis and myelitis was studied in suckling mice using routine titration procedures and fluorescent antibody staining for the identification of infected cells and there was no evidence of axonal spread of virus in the host-virus system studied.
Herpes simplex virus DNA sequences in the CNS of latently infected mice
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The results suggest that viruses that progress from the PNS into the CNS are not eliminated, but are capable of establishing a latent infection in the CNS that cannot be reactivated by explantation techniques.
Isolation of herpesviruses from trigeminal ganglia of man, monkeys, and cats.
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- 1973
The trigeminal ganglia have been suggested as the site of persistence of herpes simplex virus, a hypothesis supported to some extent by the frequent appearance of herpes lesions on the denervated area of the face within a short time of surgical section of the trigemINAL nerve root, and by the recent recovery of herpessimplex virus from the trigenital ganglia of autopsied patients.
CENTRAL NERVOUS SYSTEM SUSCEPTIBILITY TO HERPES SIMPLEX INFECTION
- Biology, MedicineJournal of neuropathology and experimental neurology
- 1978
Four days after inoculation of herpes simplex virus (HSV) on the rabbit cornea, distinctive and reproducible lesions appear in the trigeminal root entry zone, providing an easily reproducible model for further investigation of the response of nervous system tissue to HSV.
Intra-axonal location of herpes simplex virus particles.
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- 1972
There is increasing evidence that herpes simplex virus may reach the central nervous system along peripheral nerves and the recent work of Kristensson, Lycke & Sjostrand (1971a) gives further weight to the much older hypothesis that the most important mode of spread is inside the axons.
The progression of herpes simplex virus to the central nervous system of the mouse
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It appears that invasion of the central nervous system takes place only by way of the peripheral nerve, and paralysis is not prevented by circulating neutralizing antibody given 18 hours after inoculation.
Neural spread of herpes simplex virus types 1 and 2 in mice after corneal or subcutaneous (footpad) inoculation
- Medicine, BiologyJournal of the Neurological Sciences
- 1978