Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain

@article{Esiri1982HerpesSE,
  title={Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain},
  author={Margaret M. Esiri},
  journal={Journal of the Neurological Sciences},
  year={1982},
  volume={54},
  pages={209-226}
}
  • M. Esiri
  • Published 1 May 1982
  • Biology, Medicine
  • Journal of the Neurological Sciences
Neurological disease and herpes simplex virus
TLDR
Only two patients with Alzheimer's disease showed areas of brain positive for HSV antigen (VA), which suggests “coincidental disease” processes within these two patients and means that any hypothesis implicating HSV as an aetiological agent in degenerative disease must still remain extremely speculative.
Herpes simplex virus antigen detection in human acute encephalitis:
TLDR
Results suggests that, because of its high sensitivity, ABC method permits viral antigen detection not feasible with other methods, however, this method lacks of accuracy for HSV typing mainly because of probable antigens changes resulting from tissue processing.
Concurrent herpes simplex type 1 necrotizing encephalitis, cytomegalovirus ventriculoencephalitis and cerebral lymphoma in an AIDS patient
TLDR
Herpes simplex virus type 1 was shown in the nuclei and cytoplasm of certain neurons and astrocytes in the borders of the necrotized temporal lobe areas by immunohistochemistry, in situ hybridization and electron microscopy, whereas in situ Hybridization and immunohistsochemistry for CMV were negative in such areas.
Comparison of in situ DNA hybridization (ISH) and immunocytochemistry for diagnosis of herpes simplex virus (HSV) encephalitis in tissue
TLDR
Results demonstrate that immunocytochemistry and ISH are techniques of comparable sensitivity for detection of HSV in paraffin sections of acute necrotizing encephalitis brains; their combined use enhanced sensitivity, in the authors' hands, to 84%.
Resistance of rat CNS to brain stem infection with herpes simplex virus type 1
TLDR
The observed relative resistance of brain stem-derived astrocytes to replicate HSV-1 might contribute to the ability of the brain stem to withstand infection during reactivation of this virus in the trigeminal neurons.
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References

SHOWING 1-10 OF 55 REFERENCES
Herpes simplex encephalitis: a clinical and pathological analysis of twenty-two cases
TLDR
The present problem is that the firmest diagnosis is made in those patients who are most seriously ill, so that what have come to be accepted as the 'typical' clinical picture and the characteristic histopathology may in fact represent only one part of a wide clinical spectrum.
THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS : I. VIRUS PATHWAYS TO THE NERVOUS SYSTEM OF SUCKLING MICE DEMONSTRATED BY FLUORESCENT ANTIBODY STAINING
TLDR
The pathogenesis of herpes simplex virus encephalitis and myelitis was studied in suckling mice using routine titration procedures and fluorescent antibody staining for the identification of infected cells and there was no evidence of axonal spread of virus in the host-virus system studied.
Herpes simplex virus DNA sequences in the CNS of latently infected mice
TLDR
The results suggest that viruses that progress from the PNS into the CNS are not eliminated, but are capable of establishing a latent infection in the CNS that cannot be reactivated by explantation techniques.
Isolation of herpesviruses from trigeminal ganglia of man, monkeys, and cats.
  • G. Plummer
  • Biology, Medicine
    The Journal of infectious diseases
  • 1973
TLDR
The trigeminal ganglia have been suggested as the site of persistence of herpes simplex virus, a hypothesis supported to some extent by the frequent appearance of herpes lesions on the denervated area of the face within a short time of surgical section of the trigemINAL nerve root, and by the recent recovery of herpessimplex virus from the trigenital ganglia of autopsied patients.
CENTRAL NERVOUS SYSTEM SUSCEPTIBILITY TO HERPES SIMPLEX INFECTION
TLDR
Four days after inoculation of herpes simplex virus (HSV) on the rabbit cornea, distinctive and reproducible lesions appear in the trigeminal root entry zone, providing an easily reproducible model for further investigation of the response of nervous system tissue to HSV.
Intra-axonal location of herpes simplex virus particles.
TLDR
There is increasing evidence that herpes simplex virus may reach the central nervous system along peripheral nerves and the recent work of Kristensson, Lycke & Sjostrand (1971a) gives further weight to the much older hypothesis that the most important mode of spread is inside the axons.
The progression of herpes simplex virus to the central nervous system of the mouse
TLDR
It appears that invasion of the central nervous system takes place only by way of the peripheral nerve, and paralysis is not prevented by circulating neutralizing antibody given 18 hours after inoculation.
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