Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain

@article{Esiri1982HerpesSE,
  title={Herpes simplex encephalitis An immunohistological study of the distribution of viral antigen within the brain},
  author={Margaret M. Esiri},
  journal={Journal of the Neurological Sciences},
  year={1982},
  volume={54},
  pages={209-226}
}
  • M. Esiri
  • Published 1982
  • Medicine
  • Journal of the Neurological Sciences
An immunoperoxidase technique was used to map the sites of herpes simplex virus antigen (VA) within the brain in 29 autopsied cases of herpes simplex encephalitis. Attention was directed particularly to those parts of the brain that are known from pathological studies to be involved in the disease. Material was studied from cases surviving for varying periods from a few days to a few years after the onset of neurological disease. VA was found within the brain in all cases dying within 3 weeks… Expand
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229 Citations

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Distribution of herpes simplex virus DNA in the brains of human long-term survivors of encephalitis
TLDR
It is suggested that HSV-1 may persist within the human central nervous system after acute herpes simplex encephalitis, and the distribution of the viral DNA correlates better with that of the persistent inflammatory infiltrate than with the destructive lesions of the acute encephalopathy. Expand
Herpes-simplex-related antigen in human demyelinative disease and encephalitis
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Paraffin sections from human central nervous system tissues from 31 cases pathologically diagnosed as multiple sclerosis, 34 cases of other neurological diseases, 4 adult cases of HSV encephalitis, and mouse brains infected with various HSV strains were examined, suggesting HSV-related antigen may be found in a broader spectrum of human CNS lesions than has previously been recognized. Expand
Neurological disease and herpes simplex virus
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Only two patients with Alzheimer's disease showed areas of brain positive for HSV antigen (VA), which suggests “coincidental disease” processes within these two patients and means that any hypothesis implicating HSV as an aetiological agent in degenerative disease must still remain extremely speculative. Expand
Herpes simplex virus antigen detection in human acute encephalitis:
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Results suggests that, because of its high sensitivity, ABC method permits viral antigen detection not feasible with other methods, however, this method lacks of accuracy for HSV typing mainly because of probable antigens changes resulting from tissue processing. Expand
Concurrent herpes simplex type 1 necrotizing encephalitis, cytomegalovirus ventriculoencephalitis and cerebral lymphoma in an AIDS patient
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Herpes simplex virus type 1 was shown in the nuclei and cytoplasm of certain neurons and astrocytes in the borders of the necrotized temporal lobe areas by immunohistochemistry, in situ hybridization and electron microscopy, whereas in situ Hybridization and immunohistsochemistry for CMV were negative in such areas. Expand
Herpes simplex virus encephalitis in a mouse model: PCR evidence for CNS latency following acute infection
TLDR
The findings suggest that latent infection by HSV-1 may be relatively readily established in the CNS as well as in sensory ganglia, and the frequency of establishment of latency appears to be related to the neuroanatomical accessibility of each brain region to the site of entry of the virus. Expand
Immunohistological studies of immunoglobulin-containing cells and viral antigens in some inflammatory diseases of the nervous system.
Publisher Summary This chapter discusses the findings obtained from studies conducted on a number of inflammatory diseases using the immunoperoxidase technique to detect immunoglobulin-containing… Expand
Herpes simplex encephalitis Immunohistological demonstration of spread of virus via olfactory pathways in mice
Six-week-old Balb/c mice were inoculated intranasally with a suspension of HSV1 virus and the distribution of viral antigen in the brain 3-7 days later was surveyed using the immunoperoxidase… Expand
Autopsy neuropathological findings in ‘burnt out’ herpes simplex encephalitis and use of the polymerase chain reaction to detect viral DNA
TLDR
The hypothesis that herpes simplex virus may persist within the central nervous system after acute herpes encephalitis, to cause latent or low‐grade productive infection, is supported. Expand
Immunocytochemical localization of herpes simplex virus antigen in the trigeminal ganglia of experimentally infected mice
TLDR
The appearance of infected ganglion cells during the transition to latency suggests that neurons can be switched from an HSV-permissive to a non- permissive (latent) state. Expand
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