Corpus ID: 35591046

Herpes Zoster : New Preventive Perspectives

  title={Herpes Zoster : New Preventive Perspectives},
  author={S. Armando and Valente Nicoletta and P. Sara and G. Matilde and L. Silvia and Gabutti Giovanni},
Herpes Zoster, due to reactivation of latent Varicella Zoster Virus in ganglia, is common in adults 50 years of age and older. Aging and other conditions that involvea decline of VZVspecific cell-mediated immunity are related to the onset of the disease. The main complication is Postherpetic Neuralgia, a debilitating long-lasting painful condition. Pharmacological treatment may be sub-optimal and the impact on quality of life is significant, especially for older patients. A preventive approach… Expand
2 Citations
The infant experienced significant improvement and recovered completely without sequelae, and human immunodeficiency virus (HIV) serology was negative both in mother and baby. Expand
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  • Medicine
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A man presented with a painful rash that began on his left chest and spread to his left back. There are no lesions anywhere else on his body.


Prevention of herpes zoster and its painful and debilitating complications.
Immunization of older adults is a good option to prevent herpes zoster and PHN, and the burden of illness, and vaccine tolerability was good, with minor local injection site reactions the most common adverse event. Expand
Management of herpes zoster and post-herpetic neuralgia now and in the future.
The current management strategies available for the treatment of herpes zoster, including antiviral drugs, analgesic agents, anticonvulsants, tricyclic antidepressants and topical therapies are reviewed, and new drug targets are outlined. Expand
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The author discusses the natural history and incidence of primary VZV infection and herpes zoster and details the epidemiology, clinical manifestation, diagnosis, and complications of this disease. Expand
The prevention and management of herpes zoster
A live, attenuated VZV vaccine has proven to be efficacious in reducing the incidence of and morbidity associated with HZ and PHN in older adults, and the vaccine's efficacy has been shown to persist for at least 4 years, but is likely to last a lot longer. Expand
Herpes Zoster Vaccine Effectiveness against Incident Herpes Zoster and Post-herpetic Neuralgia in an Older US Population: A Cohort Study
A cohort of more than 750,000 individuals over the age of 65 years was studied to assess whether herpes zoster vaccine is effective against incident zoster and post-herpetic neuralgia in an older population. Expand
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  • Medicine
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Systemic antiviral therapy is urgently indicated in patients beyond the age of 50 years and in patients at any age with herpes zoster in the head and neck area, especially in patients with zoster ophthalmicus. Expand
Management of herpes zoster (shingles) and postherpetic neuralgia
Herpes zoster (HZ) results from recrudescence of varicella zoster virus latent since primary infection (varicella), and postherpetic neuralgia (PHN), defined as significant pain or dysaesthesia present ≥ 3 months after HZ is the most common complication. Expand
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  • Drugs & aging
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Developments in the understanding of the pathophysiology of PHN indicate possible directions for improved drug management of established PHN, although no evidence yet exists for efficacy of the drugs concerned, including new generation anticonvulsants and N-methyl-D-aspartate antagonists. Expand
Management Strategies for Herpes Zoster and Postherpetic Neuralgia
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  • Medicine
  • The Journal of the American Osteopathic Association
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Prevention of herpes zoster and PHN with prophylactic vaccination using the zoster virus vaccine is an effective strategy to reduce the morbidity of these conditions. Expand
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  • Medicine
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Herpetic facial palsies may respond to combination therapy with an antiviral plus steroid, but further research is needed to determine the benefit of such treatments. Expand