Heroin inhibits HIV-restriction miRNAs and enhances HIV infection of macrophages

@inproceedings{Wang2015HeroinIH,
  title={Heroin inhibits HIV-restriction miRNAs and enhances HIV infection of macrophages},
  author={Xu Wang and Tong-Cui Ma and J. Li and Yu Zhou and Ellen B. Geller and Martin W. Adler and Jin-song Peng and Wang Zhou and Dun-jin Zhou and Wen-zhe Ho},
  booktitle={Front. Microbiol.},
  year={2015}
}
Although opioids have been extensively studied for their impact on the immune system, limited information is available about the specific actions of opioids on intracellular antiviral innate immunity against HIV infection. Thus, we investigated whether heroin, one of the most abused drugs, inhibits the expression of intracellular HIV restriction microRNA (miRNA) and facilitates HIV replication in macrophages. Heroin treatment of macrophages enhanced HIV replication, which was associated with… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 73 REFERENCES

Opioids and HIV/HCV Infection

  • Journal of Neuroimmune Pharmacology
  • 2011
VIEW 6 EXCERPTS

A critical function

Y. Zhou, X. Wang, +3 authors L Ye
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL