Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

@article{Ettenberg2004HeroinAC,
  title={Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems},
  author={Aaron Ettenberg and Hugh O. Pettit and Floyd E. Bloom and George F. Koob},
  journal={Psychopharmacology},
  year={2004},
  volume={78},
  pages={204-209}
}
The hypothesis that separate neural systems mediate the reinforcing properties of opiate and psychomotor stimulant drugs was tested in rats trained to lever-press for IV injections of either cocaine or heroin during daily 3-h sessions. Pretreatment with the opiate receptor antagonist drug naltrexone produced dose-dependent increases in heroin self-administration, but had no effect on the rate or pattern of cocaine self-administration. Similarly, pretreatment with low doses of the dopamine… 
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TLDR
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