Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice to produce antinociception.

@article{Rady1991HeroinAO,
  title={Heroin acts on different opioid receptors than morphine in Swiss Webster and ICR mice to produce antinociception.},
  author={Jodie J Rady and Sandra C. Roerig and James M Fujimoto},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1991},
  volume={256 2},
  pages={448-57}
}
The opioid receptor types involved in supraspinal and spinal heroin-induced analgesia in Swiss Webster and ICR mice were determined by intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of opioid agonists and antagonists. Also, comparisons were made with morphine. Antinociception was measured by changes in tail-flick latency. In Swiss Webster mice, i.c.v. heroin like [D-Pen2-D-Pen5]enkephalin, a delta receptor opioid agonist, activated supraspinal delta opioid receptors as… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

Evidence for the nucleus accumbens as a neural substrate of heroin-induced immune alterations.

The Journal of pharmacology and experimental therapeutics • 2009
View 2 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-3 of 3 references

Frank A M Redegeld, Gerard A Hofman, G F Peet, Van De Loo
-1

Brown 480

D Raeburn
Brown 480

Daniel

Luke J Janssen, E Edwin
Daniel

Similar Papers

Loading similar papers…