Heroin activates Bim via c-Jun N-terminal kinase/c-Jun pathway to mediate neuronal apoptosis.

@article{Tan2013HeroinAB,
  title={Heroin activates Bim via c-Jun N-terminal kinase/c-Jun pathway to mediate neuronal apoptosis.},
  author={Minghui Tan and Zhijun Li and S Ma and J M Luo and Shi-Yuan Xu and Andrew Lu and Wei Gan and Peng Wei Su and H Lin and Sijia Li and Biqin Lai},
  journal={Neuroscience},
  year={2013},
  volume={233},
  pages={1-8}
}
Heroin is reported to cause spongiform leukoencephalopathy (SLE) in heroin addicts and the exact mechanism has not yet been identified. In the present study, we found that heroin could induce apoptosis of primary cultured cerebellar granule cells (CGCs) and Bim was upregulated both transcriptionally and post transcriptionally during CGCs apoptosis. Upregulated Bim translocated to mitochondria and Bax was activated under heroin treatment. Genetic knockdown of Bim using lentiviruses significantly… CONTINUE READING
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