Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.

@article{Kang1996HerniatedLI,
  title={Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.},
  author={James D. Kang and Helga I. Georgescu and L McIntyre-Larkin and Maja Stefanovic-Racic and William Fielding Donaldson and Christopher H. Evans},
  journal={Spine},
  year={1996},
  volume={21 3},
  pages={271-7}
}
STUDY DESIGN Herniated lumbar disc specimens were obtained from patients undergoing surgical discectomy for persistent radiculopathy and cultured in vitro to determine whether various biochemical agents were being produced. OBJECTIVES Our hypothesis is that biochemical mediators of inflammation and tissue degradation play a role in intervertebral disc degeneration and in the pathophysiology of radiculopathy. SUMMARY OF BACKGROUND DATA Low back pain with or without radiculopathy is a… CONTINUE READING
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