Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion.

@article{Harrington2000HerniatedLD,
  title={Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion.},
  author={J. Frederick Harrington and Arthur A. Messier and David A. Bereiter and Bryan Barnes and Mel H. Epstein},
  journal={Spine},
  year={2000},
  volume={25 8},
  pages={929-36}
}
STUDY DESIGN Combined prospective human cohort and prospective controlled animal model. OBJECTIVES To determine whether free glutamate is available in herniated disc material in concentrations sufficient to diffuse to glutamate receptors and affect the activity of neurons in the dorsal root ganglion that may transmit pain information. SUMMARY OF BACKGROUND DATA The severity of lumbar radicular pain cannot be fully explained by physical pressure on nerve roots or ganglions. In experimental… CONTINUE READING

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