Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.

@article{Kang1995HerniatedCI,
  title={Herniated cervical intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2.},
  author={James D. Kang and Helga I. Georgescu and L McIntyre-Larkin and Maja Stefanovic-Racic and Christopher H. Evans},
  journal={Spine},
  year={1995},
  volume={20 22},
  pages={2373-8}
}
STUDY DESIGN Herniated cervical disc specimens were obtained from patients undergoing surgical discectomy for persistent radiculopathy and cultured in vitro to determine whether various biochemical agents were being produced. OBJECTIVES Our hypothesis is that biochemical mediators of inflammation and tissue degradation play a role in cervical intervertebral disc degeneration and in the pathophysiology of cervical radiculopathy. SUMMARY OF BACKGROUND DATA Neck pain with or without… CONTINUE READING

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