Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.

Abstract

Endosomal sorting mechanisms mediated by AP-3 and BLOC-1 are perturbed in Hermansky-Pudlak Syndrome, a human genetic condition characterized by albinism and prolonged bleeding (OMIM #203300). Additionally, mouse models defective in either one of these complexes possess defective synaptic vesicle biogenesis (Newell-Litwa et al., 2009). These synaptic vesicle… (More)
DOI: 10.1523/JNEUROSCI.3400-09.2010

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Cite this paper

@article{NewellLitwa2010HermanskyPudlakPC, title={Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.}, author={Karen A. Newell-Litwa and Sreenivasulu Chintala and Susan L. Jenkins and Jean-François Par{\'e} and LeeAnne McGaha and Yoland Smith and Victor Faundez}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2010}, volume={30 3}, pages={820-31} }