Heritable sperm chromatin epigenetics: a break to remember.

@article{Meyer2017HeritableSC,
  title={Heritable sperm chromatin epigenetics: a break to remember.},
  author={Ralph G. Meyer and Chelsea C Ketchum and Mirella L. Meyer-Ficca},
  journal={Biology of reproduction},
  year={2017},
  volume={97 6},
  pages={784-797}
}
Sperm chromatin not only has a unique structure to condense and protect the paternal DNA in transit, but also provides epigenetic information that supports embryonic development. Most of the unique sperm nuclear architecture is formed during the sweeping postmeiotic chromatin remodeling events in spermiogenesis, where the majority of nucleosomes are removed and replaced by protamines. The remaining histones and other chromatin proteins are located in structurally and transcriptionally relevant… CONTINUE READING
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