Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication

Abstract

Temporal control of DNA replication has been implicated in epigenetic regulation of gene expression on the basis of observations that certain tissue-specific genes replicate earlier in expressing than non-expressing cells. Here, we show evidence that several leukocyte-specific genes replicate early in lymphocytes regardless of their transcription and also… (More)
DOI: 10.1038/ncb1006

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