Heritable factors in the severity of affective illness.

  title={Heritable factors in the severity of affective illness.},
  author={David L. Dunner and Elliot S. Gershon and Frederick K. Goodwin},
  journal={Biological psychiatry},
  volume={11 1},
A review of clinical experience with 163 patients with primary affective disorder indicates that patients with a history characterized by recurrent depression interspersed with periods of hypomania (bipolar II) may have clinical courses that are distinguishable from bipolar I (depression with histories of mania) or unipolar patients. A prior history of suicide attempt and suicide after discharge from the research unit were most frequent among bipolar II patients. The family histories of bipolar… CONTINUE READING