Heritable capture of heterochromatin dynamics in Saccharomyces cerevisiae

@inproceedings{Dodson2015HeritableCO,
  title={Heritable capture of heterochromatin dynamics in Saccharomyces cerevisiae},
  author={Anne E Dodson and Jasper Rine},
  booktitle={eLife},
  year={2015}
}
Heterochromatin exerts a heritable form of eukaryotic gene repression and contributes to chromosome segregation fidelity and genome stability. However, to date there has been no quantitative evaluation of the stability of heterochromatic gene repression. We designed a genetic strategy to capture transient losses of gene silencing in Saccharomyces as permanent, heritable changes in genotype and phenotype. This approach revealed rare transcription within heterochromatin that occurred in… CONTINUE READING
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