Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion

@article{Holmes2013HeritableRO,
  title={Heritable Remodeling of Yeast Multicellularity by an Environmentally Responsive Prion},
  author={Daniel L. Holmes and Alex K Lancaster and Susan Lindquist and Randal Halfmann},
  journal={Cell},
  year={2013},
  volume={153},
  pages={153-165}
}
Prion proteins undergo self-sustaining conformational conversions that heritably alter their activities. Many of these proteins operate at pivotal positions in determining how genotype is translated into phenotype. But the breadth of prion influences on biology and their evolutionary significance are just beginning to be explored. We report that a prion formed by the Mot3 transcription factor, [MOT3(+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces… CONTINUE READING