Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception

@article{Mogil1999HeritabilityON,
  title={Heritability of nociception I: Responses of 11 inbred mouse strains on 12 measures of nociception},
  author={Jeffrey S. Mogil and Sonya G. Wilson and Karine Bon and Seo Eun Lee and Kyungsoon Chung and Pnina Raber and Jeanne O. Pieper and Heather S. Hain and John K. Belknap and Lawrence Hubert and Gregory I. Elmer and Jin Mo Chung and Marshall Devor},
  journal={Pain},
  year={1999},
  volume={80},
  pages={67-82}
}
It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical injuries or pathologies. The possible contribution of genetic factors has, however, been largely overlooked. An emerging rodent literature documents the importance of genotype in mediating basal nociceptive sensitivity, in establishing a predisposition to neuropathic pain following neural injury, and in determining sensitivity to pharmacological agents and endogenous… 
Heritability of nociception II. `Types' of nociception revealed by genetic correlation analysis
TLDR
Three major clusters of nociception are revealed: (1) baseline thermal nOCiception, (2) spontaneously-emitted responses to chemical stimuli, and (3) baseline mechanical sensitivity and cutaneous hypersensitivity.
Paclitaxel-induced neuropathic hypersensitivity in mice: responses in 10 inbred mouse strains.
TLDR
A survey of the responses of 10 inbred mouse strains to paclitaxel injections confirms a genetic component in mechanical allodynia using this model, while dissociating mechanical hypersensitivity from other pain modalities.
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
TLDR
It is now clear that mechanical hypersensitivity and thermal hypersensitivity are genetically dissociable phenomena, and at least two distinct types of thermal hypers sensitivity: afferent‐dependent, featuring a preceding significant period of spontaneous nociceptive behavior associated with afferent neural activity, and non‐afferent‐ dependent.
Strain-dependent effects of supraspinal orphanin FQ/nociceptin on thermal nociceptive sensitivity in mice
TLDR
The data suggest that genetic variability among subject populations may underlie the inconsistent findings among researchers, and may in addition provide a promising avenue for future study of this novel neuromodulator.
Influence of Nociception and Stress-induced Antinociception on Genetic Variation in Isoflurane Anesthetic Potency among Mouse Strains
TLDR
Genetic variability in isoflurane MAC (but not MACLORR) may reflect genetic variability in the underlying sensitivity to the noxious stimulus being used to measure MAC, which is at least partially mediated by endogenous antinociceptive mechanisms activated by the tail-clip stimulus itself.
Identification of quantitative trait loci for chemical/inflammatory nociception in mice
TLDR
Evidence is provided for two statistically significant formalin test QTLs – chromosomal regions whose inheritance is associated with trait variability – on distal mouse chromosomes 9 and 10 that may illuminate the basis of individual differences in inflammatory pain, and lead to novel analgesic treatment strategies.
Screening for pain phenotypes: Analysis of three congenic mouse strains on a battery of nine nociceptive assays
TLDR
Strong evidence is found for the existence of two quantitative trait loci (i.e., genomic regions containing variability‐causing genes), one for thermal nociception on mouse chromosome (Chr) 17 (ChR 17; Tpnr3) and one for formalin test nocICEption on mice Chr 12 (Nociq3).
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
TLDR
An increase in formalin-induced inflammatory nociceptive behaviors and paw diameter in B6J versus B6N mice is observed and no strain differences were observed in mechanical or thermal hypersensitivity or in edema following the Complete Freund’s Adjuvant model of inflammatory pain, indicating specificity in the inflammatory nOCiceptive stimulus.
Sex differences in thermal nociception and morphine antinociception in rodents depend on genotype
TLDR
In a separate study in which the estrous cycle was tracked in female mice, there was evidence for an interaction between genotype and estrous phase relevant to morphine antinociception, however, estrous cyclicity did not explain the observed sex differences.
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
TLDR
An increase in formalin-induced inflammatory nociceptive behaviors and paw diameter in B6J versus B6N mice is observed and no strain differences were observed in mechanical or thermal hypersensitivity or in edema following the Complete Freund’s Adjuvant model of inflammatory pain, indicating specificity in the inflammatory nOCiceptive stimulus.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 132 REFERENCES
Heritability of nociception II. `Types' of nociception revealed by genetic correlation analysis
TLDR
Three major clusters of nociception are revealed: (1) baseline thermal nOCiception, (2) spontaneously-emitted responses to chemical stimuli, and (3) baseline mechanical sensitivity and cutaneous hypersensitivity.
The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains
TLDR
One strain, A/J, was identified as extremely resistant to formalin nociception, displaying total licking in the acute and tonic phases that was 60% and 87% lower, respectively, than the grand mean of all strains.
Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.
TLDR
In HA/LA and HAR/LAR mice, it is found that an inverse relationship exists with respect to morphine antinociceptive sensitivity in the hot-plate and acetic acid abdominal constriction tests, respectively.
Nociceptive and morphine antinociceptive sensitivity of 129 and C57BL/6 inbred mouse strains: Implications for transgenic knock‐out studies
TLDR
The findings suggest that gene targeting studies of pain are particularly subject to the aforementioned concerns, and that C57BL/6 mice represent a suboptimal background strain for such efforts.
Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ 2-opioid receptors
TLDR
Data support the possibility that Oprd1 is a QTL mediating HP sensitivity in mice, and more generally illustrate the important roles of genetic background and gender in the perception of pain.
Genetic variance in nociception and its relationship to the potency of morphine-induced analgesia in thermal and chemical tests
TLDR
A large degree of genetically‐determined variability in sensitivity to painful stimuli is demonstrated, and inherent differences in sensitive stimuli may be responsible, in part, for individual differences in the potency of morphine's antinociceptive effects.
Identification of a Sex-Specific Quantitative Trait Locus Mediating Nonopioid Stress-Induced Analgesia in Female Mice
TLDR
The present data provide further evidence of the existence of a female-specific SIA mechanism and highlight the important role of both genetic background and gender in the inhibition of pain.
Transgenic studies of pain
TLDR
This paper reviews the findings of investigations in which a transgenic mouse has been assessed for nociceptive or analgesic sensitivity and discusses the advantages and limitations of this approach to pain research.
Diminished Inflammation and Nociceptive Pain with Preservation of Neuropathic Pain in Mice with a Targeted Mutation of the Type I Regulatory Subunit of cAMP-Dependent Protein Kinase
TLDR
It is suggested that in inflammatory conditions, RIβ PKA is specifically required for nociceptive processing in the terminals of small-diameter primary afferent fibers, including small diameter trkA receptor-positive dorsal root ganglion cells.
One or two genetic loci mediate high opiate analgesia in selectively bred mice
TLDR
It is reported that the differential sensitivity of HA and LA mice to each of these analgesic manipulations appears to be determined oligogenically, by one or at the most two major genetic loci.
...
1
2
3
4
5
...