Heritability of central systolic pressure augmentation: a twin study.

  title={Heritability of central systolic pressure augmentation: a twin study.},
  author={Harold Snieder and Christopher S. Hayward and Ursula C Perks and Ronan P. Kelly and Patrick D. Kelly and Tim D. Spector},
  volume={35 2},
Less than 50% of the variance in left ventricular mass is explained by conventional factors such as age, blood pressure, and body size. Genetic influences may account for part of the unexplained variance. The central (aortic) pressure augmentation index has been suggested as a noninvasive measure of pulsatile load, which is a likely determinant of left ventricular mass. We quantified the genetic influence on augmentation index and determined the extent to which this influence is dependent on… CONTINUE READING
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A twinpronged attack on complex traits

  • NG Martin, DI Boomsma, G Machin
  • Nature Genet
  • 1997

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