Heritability of borderline personality disorder features is similar across three countries

  title={Heritability of borderline personality disorder features is similar across three countries},
  author={Marijn A. Distel and Timothy J. Trull and Catherine A. Derom and Evert Thiery and Marisa Grimmer and Nicholas G. Martin and Gonneke Willemsen and Dorret I. Boomsma},
  journal={Psychological Medicine},
  pages={1219 - 1229}
Summary Background Most of our knowledge about borderline personality disorder features has been obtained through the study of clinical samples. Although these studies are important in their own right, they are limited in their ability to address certain important epidemiological and aetiological questions such as the degree to which there is a genetic influence on the manifestation of borderline personality disorder features. Though family history studies of borderline personality disorder… 

Familial Resemblance of Borderline Personality Disorder Features: Genetic or Cultural Transmission?

Results showed that resemblance among biological relatives could completely be attributed to genetic effects and significant resemblance between spouses was observed, which was best explained by phenotypic assortative mating.

Etiological features of borderline personality related characteristics in a birth cohort of 12-year-old children

Borderline personality related characteristics measured at age 12 years were highly heritable, were more common in children who had exhibited poor cognitive function, impulsivity, and more behavioral and emotional problems at age 5 years, and co-occurred with symptoms of conduct disorder, depression, anxiety, and psychosis.

Genome-wide analyses of borderline personality features

This work presents results from a first genome-wide association study of BP features, which shows a promising signal on chromosome 5 corresponding to SERINC5, a protein involved in myelination, which is suggested as possibly having a role in the development of psychiatric disorders characterized by lack of social interaction.

Individual differences in borderline personality traits: A genetic perspective

t he effect of non-response on health and lifestyle measures has received extensive study, showing at most relatively modest effects. Nonresponse bias with respect to personality has been less

Genetic epidemiology of borderline personality disorder

Borderline personality disorder (BPD) is a severe personality disorder characterized by impulsivity, affective instability, relationship problems and identity problems. BPD affects 1-2% of the

Genetic and Environmental Causes of Individual Differences in Borderline Personality Disorder Features and Loneliness are Partially Shared

Analysis of genetically informative data from two large nonclinical samples of adult twin pairs from Australia and the Netherlands suggests common etiological factors in loneliness and borderline personality features.

Structure of genetic and environmental risk factors for symptoms of DSM-IV borderline personality disorder.

The results indicate that most of the genetic effects on the individual BPD criteria derive from 1 highly heritable general BPD factor, whereas the environmental influences were mostly criterion specific.



Borderline personality disorder features in nonclinical young adults: 1. Identification and validation.

Two studies were conducted that sought to (a) establish and validate a self-report method of identifying nonclinical young adults who present with significant borderline personality disorder (BPD)

Genetic and environmental contributions to dimensions of personality disorder.

The heritability of the basic dimensions of personality disorder and the relative proportions of the variance attributable to genetic and environmental sources are estimated to suggest a continuity between normal and disordered personality.

The prevalence of personality disorders in a community sample.

Personality disorders were found to be prevalent, with avoidant, schizoid, and paranoid PDs more common, and borderline PD less common than what is usually reported.

Genetics of personality disorders: perspectives from personality and psychopathology research.

Genetic links to personality disorders from the domains of normal personality and Axis I disorders are reviewed and greater attention to dimensional phenotypic measures and multivariate designs can yield more definitive answers regarding the correct subtyping and probable etiology of personality disorders.

Prevalence and correlates of personality disorder in Great Britain

Background Epidemiological data on personality disorders, comorbidity and associated use of services are essential for health service policy. Aims To measure the prevalence and correlates of

Structural relations between borderline personality disorder features and putative etiological correlates.

  • T. Trull
  • Psychology
    Journal of abnormal psychology
  • 2001
A multivariate model that included parental psychopathology, childhood abuse, and personality factors provided an adequate fit to the data and supported the contention that the personality traits disinhibition and negative affectivity underlie BPD features.

Familial aggregation of adolescent personality disorders.

The results of this study support the validity of Axis II diagnoses, particularly avoidant and borderline disorders, in adolescents.

A twin study of personality disorders.

PDs seem to be more strongly influenced by genetic effects than almost any axis I disorder, and more than most broad personality dimensions, but there is a large variation in heritability among the different PDs, probably partly because of a moderate sample size and low prevalence of the specific disorders.

Comorbidity of borderline personality disorder with other personality disorders in hospitalized adolescents and adults.

The results suggest that the borderline personality disorder diagnosis may represent a more diffuse range of psychopathology in adolescents than in adults.

Gender differences in personality disorders.

OBJECTIVE The aim of this study was to assess gender differences in personality disorders. Since heterogeneity of axis I diagnoses could introduce variability in the assessment of axis II diagnoses,